Extracellular volume fraction correlates with myocardial stiffness and allows for differentiation between impaired active relaxation and passive stiffness in heart failure with preserved ejection fraction
نویسندگان
چکیده
Extracellular volume fraction correlates with myocardial stiffness and allows for differentiation between impaired active relaxation and passive stiffness in heart failure with preserved ejection fraction Karl-Philipp Rommel, Maximilian von Roeder, Thomas Stiermaier, Konrad Latuscynski, Christian Oberueck, Stephan Blazek, Marcus Sandri, Christian F Luecke, Matthias Gutberlet, Gerhard Schuler, Philipp Lurz
منابع مشابه
Extracellular Volume Fraction for Characterization of Patients With Heart Failure and Preserved Ejection Fraction.
BACKGROUND Optimal patient characterization in heart failure with preserved ejection fraction (HFpEF) is essential to tailor successful treatment strategies. Cardiac magnetic resonance (CMR)-derived T1 mapping can noninvasively quantify diffuse myocardial fibrosis as extracellular volume fraction (ECV). OBJECTIVES This study aimed to elucidate the diagnostic performance of T1 mapping in HFpEF...
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Heart failure with preserved ejection fraction (HFpEF) is highly prevalent and is frequently associated with metabolic risk factors. Patients with HFpEF have only a slightly lower mortality than patients with HF and reduced EF. The pathophysiology of HFpEF is currently incompletely understood, which precludes specific therapy. Both HF phenotypes demonstrate distinct cardiac remodeling processes...
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BACKGROUND The purpose of this study was to determine whether patients with heart failure and a preserved ejection fraction (HFpEF) have an increase in passive myocardial stiffness and the extent to which discovered changes depend on changes in extracellular matrix fibrillar collagen and cardiomyocyte titin. METHODS AND RESULTS Seventy patients undergoing coronary artery bypass grafting under...
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Increased myocardial fibrosis is considered to be a key underlying pathological mechanism in heart failure with preserved ejection fraction (HFpEF), with increased myocardial stiffness resulting in left ventricular dysfunction. Direct measurement of fibrosis via histology is not feasible; however, noninvasive imaging approaches now offer the potential for quantification. Improved fibrosis asses...
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